We have a new understanding of the fundamental gene networks that make bacteria so resilient to environmental stress and, increasingly, to antibacterial drugs.
Researchers at Stanford and UC-San Francisco have performed the first comprehensive survey of the central genes and proteins essential to bacterial life. The study, which combined a new variant of CRISPR gene-editing technology with automated cell imaging, generated a new understanding of the fundamental gene networks that make bacteria so resilient to environmental stress and, increasingly, to antibacterial drugs. The research also demonstrated a practical approach to identifying the mechanism of action of potential new antibiotic compounds, which the researchers hope can be harnessed to aid the design of better drugs to fight a growing epidemic of antibiotic resistance.
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