Resilience and Epigenesis
There is increasing evidence that trauma in early childhood can induce epigenetic effects, and these are also reflected in changes in mitochondrial morphology and dysfunction, and co-morbidity involving diverse physical and psychological indicators
There is increasing evidence that trauma in early childhood can induce epigenetic effects, and these are also reflected in changes in mitochondrial morphology and dysfunction, and co-morbidity involving diverse physical and psychological indicators. One study, entitled “When the serotonin gene meets adversity” states:
“The neural and molecular mechanisms by which environmental adversity in early life increases disease risk in adulthood are not known but may include epigenetic programming of gene expression during development. Epigenetic mechanisms, such as DNA methylation and chromatin modification, are dynamic and reversible and may also provide targets for intervention strategies. Animal models amenable to genetic manipulation are useful in the identification of molecular mechanisms underlying epigenetic programming by adverse environments and individual differences in resilience to stress. Therefore, deeper insight into the role of epigenetic regulation in the process of neurodevelopmental programmes is likely to result in early diagnosis of affective spectrum disorders and will contribute to the design of innovative treatments targeting neural pathways that foster resilience.”
- Is resilience an epigenetic phenomenon?
- Resilience under conditions of extreme stress: a multilevel perspective
- Epigenetics of Subcellular Structure Functioning in the Origin of Risk or Resilience to Comorbidity of Neuropsychiatric and Cardiometabolic Disorders
- When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience